Al Wehdat, who won 2-1 when the teams met in September, sits three points clear of UAE's Sharjah FC with Iran's Sepahan a further point adrift.
UAE's Sharjah will host FC Istiklol, with the Tajikistan club yet to register a point on the board.
The Sepahan and Al Wehdat match will be held at the Grand Hamad Stadium in Doha on Tuesday.
Sharjah will also meet Istiklol at the Sharjah Stadium in Sharjah.
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